Thermo Fisher Scientific SETD7 Polyclonal Antibody
SETD7 단백질을 인식하는 Thermo Fisher의 폴리클로날 항체로, 인간·마우스·원숭이·랫트에 반응합니다. Western blot과 immunocytochemistry에 적합하며, 고순도 항원 친화 크로마토그래피로 정제되었습니다. 히스톤 H3 Lys-4 단일메틸화 연구에 활용됩니다.
- 카탈로그번호
- PA517317
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SETD7 Polyclonal Antibody
Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:25 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the human SET7/SET9 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10982735 |
Product Specific Information
- It is not recommended to aliquot this antibody.
- This antibody is not cross-reactive with other SET domain-containing proteins.
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3.
H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation.
Plays a central role in the transcriptional activation of genes such as collagenase or insulin.
Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription.
Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K motif in substrate proteins.
Monomethylates Lys-189 of TAF10, increasing its affinity for RNA polymerase II.
Monomethylates Lys-372 of p53/TP53, stabilizing p53/TP53 and enhancing transcriptional activation.
(Source: UniProt)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.