Thermo Fisher Scientific PKM2 Polyclonal Antibody
PKM2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 검증 완료. 인간 PKM2 N-말단 펩타이드(aa 1-50)를 면역원으로 사용. 고순도 친화 크로마토그래피 정제, PBS + sucrose buffer, -20°C 보관.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the N-terminal region of human PKM2 (aa 1–50) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2884631 |
Product Specific Information
Immunogen sequence:
MSKPHSEAGT AFIQTQQLHA AMADTFLEHM CRLDIDSPPI TARNTGIICTStorage guidance:
- Short term: 2–8°C, up to 1 week
- Long term: -20°C in small aliquots to prevent freeze-thaw cycles
Predicted homology:
Cow: 86%; Dog: 86%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 100%; Rabbit: 86%; Rat: 93%
Target Information
PKM2 (Pyruvate Kinase M2) catalyzes the conversion of phosphoenolpyruvate to pyruvate and ATP.
It interacts with thyroid hormone, mediating metabolic effects induced by thyroid hormones.
PKM2 also binds Opa protein, a bacterial outer membrane protein involved in gonococcal adherence and invasion of human cells, suggesting a role in bacterial pathogenesis.
Three alternatively spliced transcript variants encoding two distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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