Thermo Fisher Scientific HTRA1 Polyclonal Antibody
HTRA1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB, IHC, ICC 등 다양한 응용에 적합. 인간 및 마우스 반응성. 고순도 정제 및 안정적 저장 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide between 116–147 amino acids from the N-terminal region of human HtrA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.45 mg/mL |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2122815 |
Target Information
HtrA1 is a 51 kDa protein belonging to the highly conserved mammalian HtrA serine protease family. It is a human homolog of bacterial HtrA and includes a secretory signal sequence, IGFBP-binding domain, and a Kazal-type serine-protease inhibitor domain at the N-terminus, along with a trypsin-like serine/protease domain and a PDZ domain at the C-terminus.
HtrA1 regulates cell growth and inhibits signaling mediated by TGF-beta family members. It is upregulated in the placenta during pregnancy, playing roles in implantation and placental physiology. HtrA1 also regulates IGF availability by cleaving IGF-binding proteins, acts as a tumor suppressor, and is downregulated in ovarian cancers and melanomas. Its involvement in osteoarthritis suggests therapeutic potential. Northern blot analysis shows high expression in placenta.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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