Thermo Fisher Scientific PYGL Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

This gene encodes a homodimeric protein that catalyzes the cleavage of α-1,4-glucosidic bonds to release glucose-1-phosphate from liver glycogen stores. The protein switches from inactive phosphorylase B to active phosphorylase A by phosphorylation of serine residue 15. Activity is regulated by multiple allosteric effectors and hormonal controls. Humans have three glycogen phosphorylase genes encoding distinct isozymes primarily expressed in liver, brain, and muscle. The liver isozyme supports systemic glycemic demands, while the others serve local tissues. Mutations in the liver isozyme cause glycogen storage disease type VI (Hers disease), leading to moderate hypoglycemia, mild ketosis, growth retardation, and hepatomegaly. Alternative splicing produces multiple transcript variants.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.