Thermo Fisher Scientific Phospho-PKC alpha (Ser657) Polyclonal Antibody
PKC alpha 단백질의 Ser657 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Western blot에 적합하며 Human 및 Rat 반응성 확인. 항원 친화 크로마토그래피로 정제된 액상 제품으로 안정적 장기 보관 가능.
- 판매단위
- pk
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Applications
- Western Blot (WB): 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of Human PKC alpha (phospho Ser657). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.49 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736408 |
Product Specific Information
- Positive Control: HeLa
- Predicted Reactivity: Mouse (100%), Rat (100%), Rabbit (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The PKC family of serine/threonine kinases, including PRKCA (PKC alpha), is activated intracellularly by signal transduction pathways. In humans, at least 12 different PKC polypeptides have been identified. These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action, response to extracellular signals, and substrate specificity.
PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca²⁺- and phospholipid-dependent. Protein kinase C (PKC) can be activated by calcium and diacylglycerol and phosphorylates diverse protein targets involved in cellular signaling pathways.
PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member has a distinct expression profile and cellular role. PKC alpha is implicated in processes such as cell adhesion, transformation, cell cycle regulation, and cardiac contractility.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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