Thermo Fisher Scientific RTCA Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:1,000
• Publications: -

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200
• Publications: -

Product Specifications

Product Specific Information

• Detects endogenous protein at a molecular weight of 39 kDa.
• Purity is >95% by SDS-PAGE.

Target Information

RTCD1 catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA.
The mechanism of action occurs in three steps:

1. Adenylation of the enzyme by ATP
2. The enzyme acts on RNA-N3'P to produce RNA-N3'PP5'A
3. A non-catalytic nucleophilic attack by the adjacent 2'-hydroxyl on the phosphorus in the diester linkage produces the cyclic end product

The biological role of this enzyme is unknown but it is likely to function in RNA processing. Two isoforms are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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