Thermo Fisher Scientific Phospho-ErbB3 (Tyr1197) Polyclonal Antibody
ERBB3 Tyr1197 인산화 부위를 인식하는 rabbit polyclonal antibody로, Western blot, IHC, ICC/IF에 사용 가능. Human, Mouse, Rat 반응성. 액상 형태, 1 mg/mL 농도, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ERBB3 (Accession P21860), corresponding to amino acid residues around phosphorylated Tyr1197 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816957 |
Product Specific Information
This antibody detects endogenous levels of ERBB3 only when phosphorylated at Tyr1197.
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family. ErbB3 is over-expressed in various tumors of the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents. The ErbB3 gene, located on the long arm of human chromosome 12 (12q13), encodes a transmembrane receptor tyrosine kinase that forms heterodimers with other EGF receptor family members, leading to activation of cell proliferation or differentiation pathways. Alternate splice variants encoding different isoforms of ErbB3 have been identified, including secreted forms that modulate membrane-bound receptor activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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