Thermo Fisher Scientific Phospho-ErbB3 (Ser686) Polyclonal Antibody
Phospho-ErbB3 (Ser686) 폴리클로날 항체로, 인간, 마우스, 랫트 시료에서 인산화된 HER3/ErbB3 단백질 검출에 적합합니다. Western blot 및 IHC(P) 적용 가능하며, 고순도 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ERBB3 (Accession P21860), corresponding to amino acid residues around phosphorylated Ser686 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816956 |
Product Specific Information
This antibody detects endogenous levels of HER3/ErbB3 only when phosphorylated at Ser686.
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors that binds ligands in the heregulin family. It is over-expressed in various tumors, including those of the prostate, bladder, breast, stomach, pancreas, and colon. Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on chromosome 12q13 and encodes a 160/180 kDa glycoprotein receptor tyrosine kinase. It forms heterodimers with other EGF receptor family members, leading to activation of pathways involved in cell proliferation and differentiation. Alternative splicing results in multiple isoforms, including a secreted form that modulates membrane-bound receptor activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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