Thermo Fisher Scientific Mannose Receptor 1 Polyclonal Antibody

Applications and Tested Dilutions

View 1 publication

Product Specifications

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity: Macrophage mannose receptor 1 (CD206).

Target Information

CD206 (also known as MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the pattern recognition receptor family. It is predominantly expressed in tissue macrophages, dendritic cells, certain endothelial cells, and sperm cells.

CD206 plays a role in innate and adaptive immune responses and is also expressed on microglia and mato cells of the brain, but not on astrocytes or neurons. It mediates recognition and uptake of macromolecules such as modified lipoproteins, advanced glycation end products (AGEs), and amyloid β-protein (Aβ).

While CD206 is primarily associated with cell adhesion and host defense mechanisms, it has been implicated in atherosclerosis and amyloid β deposition in Alzheimer’s disease. The CD206 gene encodes class A macrophage scavenger receptors with three isoforms (1, 2, 3) generated by alternative splicing:

• Type 1 and 2: Functional receptors mediating endocytosis of modified LDLs.
• Type 3: Non-functional for endocytosis due to altered intracellular processing; may exert a dominant negative effect on types 1 and 2.

CD206 dysfunction has been associated with diseases such as leprosy and Gaucher’s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.