Thermo Fisher Scientific Glucocorticoid Receptor Monoclonal Antibody (6E6)
Glucocorticoid Receptor(NR3C1)을 인식하는 마우스 단클론 항체로, WB, IHC, ICC, Flow, ELISA 등 다양한 응용에 적합. 인간 시료에 반응하며 약 86kDa 단백질 검출. 단기 4°C, 장기 -20°C 보관 권장.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Glucocorticoid Receptor Monoclonal Antibody (6E6)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6E6 |
| Immunogen | Purified recombinant fragment of human NR3C1 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152837 |
Product Specific Information
MA5-15801 targets NR3C1 in indirect ELISA, FACS, IF, IHC, and WB applications and shows reactivity with human samples.
The immunogen is a purified recombinant fragment of human NR3C1 expressed in E. coli.
MA5-15801 detects NR3C1, which has a predicted molecular weight of approximately 86 kDa.
Target Information
Glucocorticoid Receptor (NR3C1) is a receptor for glucocorticoids that functions as both a transcription factor and a regulator of other transcription factors. It is found in heteromeric cytoplasmic complexes with heat shock factors and immunophilins. Upon ligand binding, it translocates to the nucleus.
The receptor is expressed in the heart, including atria, ventricles, aorta, and other cardiac tissues.
Alternate splicing and promoter usage produce multiple transcript variants encoding identical or different isoforms.
Mutations in NR3C1 can cause glucocorticoid resistance.
The receptor binds steroids such as dexamethasone with nanomolar affinity and requires a complex of chaperone proteins for ligand activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.