Thermo Fisher Scientific Tau Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Positive control: Cerebrum tissue
• Cellular location: Cytoplasm, cytosol, membrane

Target Information

Tau is a neuronal microtubule-associated protein predominantly localized on axons. Its primary function is to promote tubulin polymerization and stabilize microtubules. The C-terminus binds axonal microtubules, while the N-terminus interacts with neural plasma membrane components, suggesting Tau acts as a linker between cytoskeletal and membrane structures.

Axonal polarity is determined by TAU/MAPT localization within the neuronal cell body. Short Tau isoforms provide cytoskeletal plasticity, whereas longer isoforms contribute to stabilization. In its hyper-phosphorylated form, Tau constitutes paired helical filaments (PHF), the main component of neurofibrillary tangles in Alzheimer’s disease. Hyper-phosphorylation disrupts Tau’s microtubule-binding function, leading to microtubule destabilization and neuronal degeneration.

Tau phosphorylation is mediated by multiple kinases, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in neurofibrillary lesions associated with other neurodegenerative diseases such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.