Thermo Fisher Scientific Tau Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 0.1–1 µg/mL

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 2–10 µg/mL

Product Specifications

Product Specific Information

• Positive control: Cerebrum tissue
• Cellular location: Cytoplasm, cytosol, membrane

Target Information

Tau is a neuronal microtubule-associated protein found predominantly on axons. It promotes tubulin polymerization and stabilizes microtubules. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, functioning as a linker between both structures. Tau localization determines axonal polarity within neurons. Short isoforms contribute to cytoskeletal plasticity, whereas longer isoforms aid in stabilization.

In its hyper-phosphorylated form, Tau becomes the major component of paired helical filaments (PHF), the building blocks of neurofibrillary lesions in Alzheimer’s disease (AD) brains. Hyper-phosphorylation impairs microtubule binding, leading to destabilization and neuron degeneration in AD. Several kinases phosphorylate Tau, including GSK-3β, PKA, cdk5, and casein kinase II. Hyper-phosphorylated Tau is also found in neurofibrillary lesions in other CNS disorders such as Pick’s disease, frontotemporal dementia, corticobasal degeneration, and progressive supranuclear palsy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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