Thermo Fisher Scientific Mouse SIGIRR Synthetic Peptide
마우스 SIGIRR 단백질의 C-말단 15개 아미노산 서열로 구성된 합성 펩타이드입니다. 항체 PA5-20078과 함께 차단 실험용으로 사용 가능합니다. 정제된 액상 형태로 제공되며, PBS 완충액에 0.1% BSA와 0.02% sodium azide를 포함합니다.
- 카탈로그번호
- PEP0196
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the carboxy terminus of mouse SIGIRR.
PEP-0196 can be used as a blocking peptide with polyclonal antibody PA5-20078.
Target Information
SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily. Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both.
SIGIRR has only one Ig domain in its extracellular portion, whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of Drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI.
A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFκB, unlike similar fusion proteins of other IL-1R related molecules. Phylogenetic data suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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