Thermo Fisher Scientific Mouse ST2 Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the amino terminus of mouse ST2.
PEP-0195 can be used as a blocking peptide with polyclonal antibody PA5-20077.

Target Information

IL-33R, also known as ST2, is a receptor for IL-33. It belongs to the IL-1 receptor family of innate receptors.
Its extracellular domain consists of three Ig-like domains that directly interact with its co-receptor IL-1RAcP and the ligand alarmin, IL-33.
IL-33 binding triggers the association of the IL-33R complex with adaptor proteins MyD88, IRAK1, IRAK4, and TRAF6, leading to activation of NF-κB and MAPK pathways.
This activation induces the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13.

Two common isoforms of IL-33R resulting from alternative splicing are:

• ST2L: membrane-bound form
• ST2S: soluble form

The membrane-bound form can be released by proteolytic cleavage, while the soluble form acts as a decoy to dampen IL-33 signaling.
IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, expression is also found on ILC2 and Th2 cells.
IL-33R signaling has been implicated in various immune conditions including allergies, arthritis, atherosclerosis, and sepsis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.