Thermo Fisher Scientific Human RNF216 Synthetic Peptide
인간 RNF216(TRIAD3A) 아미노 말단 15개 아미노산 서열에 해당하는 합성 펩타이드입니다. 항체 PA5-20079의 블로킹 펩타이드로 사용 가능하며, NF-κB 및 TLR 신호전달 연구에 활용됩니다. 고순도 액상 형태로 제공되며 -20°C에서 보관합니다.
- 카탈로그번호
- PEP0197
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 15 amino acids near the amino terminus of human TRIAD3A.
PEP-0197 can be used as a blocking peptide with polyclonal antibody PA5-20079.
Target Information
Activation of NF-κB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by adapter molecules such as TRIF, TIRAP, and MyD88.
Several regulatory mechanisms exist to control TLR signal transduction, including inhibition of TLR expression and signaling by molecules such as ST2 and SIGIRR.
Another mechanism involves ubiquitinization of selected TLRs by TRIAD3A, an E3 ubiquitin-protein ligase. TRIAD3A, a RING finger protein, can bind to TLR4 and TLR9, and to a lesser extent TLR3 and TLR5, catalyzing ubiquitization of these molecules.
Overexpression of TRIAD3A promotes degradation of TLR4 and TLR9, reducing signal-specific activation by their ligands. Conversely, depletion of TRIAD3A enhances TLR activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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