Thermo Fisher Scientific Natalizumab Chimeric Recombinant Mouse Monoclonal Antibody (Natalizumab)
Natalizumab 키메라 재조합 마우스 단클론 항체로 인간 α4β1 및 α4β7 인테그린에 결합합니다. Flow cytometry 및 inhibition assay에 사용 가능하며, HEK293 발현 시스템에서 생산된 IgG1, kappa 형 항체입니다. 연구용으로 다발성 경화증 및 크론병 관련 연구에 적합합니다.
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Applications
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | Natalizumab |
| Immunogen | The RAMOS cell line, a non-EBV releasing cell line, injected into mice. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody binds to the alpha 4 subunit of alpha 4 Beta 1 (also known as very late antigen 4 [VLA-4] or CD49d-CD29) and alpha 4 Beta 7 integrin.
Target Information
Natalizumab is a recombinant, humanized monoclonal antibody that binds to alpha4beta1-integrin and blocks its interaction with vascular cell adhesion molecule-1 (VCAM-1). It can be used for the treatment of relapsing remitting multiple sclerosis and Crohn’s disease. Natalizumab is the first targeted therapy that blocks an essential mechanism for lymphocyte entry to the CNS, thus preventing acute demyelinating relapses.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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