Thermo Fisher Scientific Carbonic Anhydrase IX Chimeric Recombinant Mouse Monoclonal Antibody (M75)
인간 Carbonic Anhydrase IX를 인식하는 마우스 IgG1 재조합 단일클론 항체(M75). WB, IHC, ELISA 등 다양한 응용에 사용 가능. 고순도 Protein A 정제, 1 mg/mL 농도, 액상 형태. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (Paraffin) (IHC (P)): Assay-dependent
- ELISA: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host/Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | M75 |
| Immunogen | The original antibody was generated by immunizing BALB/C mice with MaTu-infected HeLa cells (sequence PGEEDLP). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
Product Specific Information
This antibody is specific for the sequence PGEEDLP, which is repeated several times between the 61st and 96th amino acid residues of human carbonic anhydrase IX’s PG domain.
Target Information
Carbonic anhydrase (CA) is an enzyme that catalyzes the rapid interconversion of carbon dioxide and water into carbonic acid, protons, and bicarbonate ions. It is abundant in mammalian tissues and plays a critical role in pH regulation.
CA IX is highly inducible under hypoxic conditions via HIF-1 alpha and serves as a reliable histochemical marker of hypoxia due to its membrane localization and stability. Inhibition of CA IX increases cell death under hypoxia, highlighting its biological importance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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