Thermo Fisher Scientific FADD Recombinant Rabbit Monoclonal Antibody (ARC0415)
FADD 단백질을 인식하는 토끼 단클론 항체로, Western blot과 ELISA에 적합합니다. 재조합 HEK293 세포에서 발현되었으며, 고순도의 Affinity Chromatography로 정제되었습니다. PBS/glycerol 완충액에 보관되며, 세포 사멸 신호 연구에 활용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC0415 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20–150 of human FADD (Q13158) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2849134 |
Product Specific Information
Immunogen sequence:
LTELKFLCLG RVGKRKLERV QSGLDLFSML LEQNDLEPGH TELLRELLAS LRRHDLLRRV DDFEAGAAAG AAPGEEDLCA AFNVICDNVG KDWRRLARQL KVSDTKIDSI EDRYPRNLTE RVRESLRIWK N
Target Information
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain, allowing recruitment of caspase-8 and activation of the cysteine protease cascade. Knockout studies in mice also suggest its importance in early T cell development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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