Thermo Fisher Scientific CSF1R Chimeric Recombinant Rabbit Monoclonal Antibody (AFS98)
마우스 CSF1R(CD115)을 인식하는 키메릭 재조합 토끼 단클론 항체로, WB, IHC, ICC/IF, Flow Cytometry 등 다양한 분석에 사용 가능. HEK293 세포에서 발현되며 Protein A로 정제된 고순도 항체. 면역세포 분화 및 염증 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | Assay-dependent |
| Immunohistochemistry (IHC) | Assay-dependent |
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | AFS98 |
| Immunogen | This antibody was raised against CD115. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074693 |
Product Specific Information
This antibody recognizes mouse M-CSFR (CD115, CSF-1R), a membrane protein involved in tissue macrophage and osteoclast differentiation and proliferation.
Target Information
CSF1R (FMS) is a tyrosine kinase transmembrane receptor involved in macrophage production, differentiation, and function, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through oligomerization and transphosphorylation.
It plays an essential role in regulating survival, proliferation, and differentiation of hematopoietic precursor cells, particularly mononuclear phagocytes such as macrophages and monocytes. CSF1R promotes proinflammatory chemokine release in response to IL34 and CSF1, contributing to innate immunity and inflammatory processes.
Mutations in the CSF1R gene have been linked to predisposition to myeloid malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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