Thermo Fisher Scientific IL10RA Chimeric Recombinant Rabbit Monoclonal Antibody (1B1.3a)
마우스 IL-10 수용체를 인식하는 재조합 래빗 단클론 항체. ICC/IF, Flow Cytometry, Inhibition Assay에 사용 가능. HEK293 세포에서 발현되며 Protein A로 정제됨. 비결합형 액상 형태로 제공되며, 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL |
| Flow Cytometry (Flow) | 1:100 |
| Inhibition Assays (IA) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1B1.3a |
| Immunogen | Purified recombinant extracellular region of mouse Interleukin 10 Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074692 |
Product Specific Information
This antibody recognises mouse IL-10R, a cell surface glycoprotein receptor for anti-inflammatory IL-10.
The epitope recognised by this antibody has been localised to the ligand-binding domain within the extracellular region of mouse IL-10R.
Target Information
The protein encoded by this gene is a receptor for interleukin 10 and is structurally related to interferon receptors.
It mediates the immunosuppressive signal of IL-10, inhibiting synthesis of proinflammatory cytokines.
This receptor promotes survival of progenitor myeloid cells via the insulin receptor substrate-2/PI 3-kinase/AKT pathway.
Activation leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.
Two transcript variants, one protein-coding and one non-coding, have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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