Thermo Fisher Scientific TLR2 Chimeric Recombinant Rabbit Monoclonal Antibody (TL2.1)

Applications

Product Specifications

Product Specific Information

Specificity: This antibody is specific to TLR2 (extracellular domain) and does not cross-react with human TLR1 or TLR4.
TLR2 is involved in the immunological response against bacterial lipoproteins and other microbial cell wall components.

Target Information

TLR2 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity.
TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate kinases and transcription factors including PKC alpha/beta and NF-kappa-B.
TLR2 forms heterodimers with TLR1 or TLR6, recognizing bacterial and mycoplasma lipoproteins respectively.
TLRs are highly conserved across species and share structural and functional similarities.
TLR2 is expressed abundantly in peripheral blood leukocytes, mediating host response to Gram-positive bacteria and yeast via NF-kappaB stimulation.
It aids in recognition of pathogen-associated molecular patterns (PAMPs) and cytokine production for effective immunity.
Ten human homologs of TLRs (TLR1–10) have been described.
TLR2 is expressed in tonsils, microglia, lymph nodes, appendices, and activated B-cells in germinal centers.
Highest expression is found in CD14+ monocytes, followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells.
Expression is regulated by immune modifiers: LPS, GM-CSF, IL-1, and IL-10 upregulate TLR2; IL-4, IFN-gamma, and TNF downregulate its expression in monocytes.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.