Thermo Fisher Scientific Calnexin Polyclonal Antibody
Calnexin 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체로, Western blot 및 IHC에 사용 가능. 인간, 마우스, 랫, Xenopus 반응성. ER 내 단백질 접힘 연구에 적합하며, 안정적인 장기 보관 가능.
- 카탈로그번호
- OSC00161W-150UL
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Xenopus |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from the lumenal region of human Calnexin (MHC I antigen-binding protein p88) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not Determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
Specificity of this antibody: Calnexin
Target Information
Calnexin, also referred to as IP90, p88, and p90, is an approximately 90 kDa integral membrane protein of the endoplasmic reticulum (ER).
It functions as a molecular chaperone, assisting in proper folding and assembly of polypeptides.
Calnexin associates with MHC class I heavy chains, partial complexes of T cell receptor and B cell membrane immunoglobulin, but not with completed receptor complexes.
It retains incompletely or improperly folded proteins in the ER.
Soluble ER resident proteins such as GRP78, GRP94, and protein disulfide isomerase contain the KDEL sequence for ER retention, whereas integral membrane proteins like calnexin lack this sequence but have positively charged cytosolic residues ensuring ER localization.
Calnexin structure includes:
- ER luminal domain (461 amino acids)
- Transmembrane segment (22 amino acids)
- Cytoplasmic tail (89 amino acids)
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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