Thermo Fisher Scientific B2M Monoclonal Antibody (OTI1A9), TrueMAB
Human B2M 단백질을 인식하는 Mouse monoclonal antibody로, Western blot, IHC, ELISA에 사용 가능. 고순도의 Affinity chromatography 정제, PBS/BSA/glycerol buffer로 안정화. 연구용으로 항원 처리 및 MHC 관련 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1A9 |
| Immunogen | Purified native Human beta-2 Microglobulin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Beta-2-microglobulin (B2M) is a 12–14 kDa protein that forms part of the major histocompatibility complex (MHC) class I. It is associated with HLA Class I antigens and expressed on various cell types including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial, and epithelial cells, but absent on erythrocytes. It is also found freely in plasma.
The amino acid sequence of B2M is homologous to immunoglobulin constant regions, forming a beta-pleated sheet structure. B2M participates in antigen processing and presentation, TCR signaling, and downstream signaling in naive CD8+ cells. The B2M gene is located on chromosome 15, and mutations may cause hypercatabolic hypoproteinemia. B2M levels are used clinically to assess renal function and as a prognostic marker for HIV infection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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