Thermo Fisher Scientific MSR1 Monoclonal Antibody (OTI8C11), TrueMAB
인간 MSR1 단백질(aa 197-451)에 특이적인 Mouse IgG1 단클론 항체로, WB 및 IHC(P)에 사용 가능. 비결합형 액상 항체이며, 고순도 친화 크로마토그래피 정제. CD204 관련 연구 및 대식세포 기능 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI8C11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 197–451 of human MSR1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD204 gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene.
These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer’s disease, and host defense.
The isoforms type 1 and type 2 are functional receptors and mediate endocytosis of modified low-density lipoproteins (LDLs).
Isoform type 3 does not internalize modified LDL (acetyl-LDL) due to altered intracellular processing and is trapped within the endoplasmic reticulum, inhibiting the function of types 1 and 2 when co-expressed.
Diseases associated with MSR1 include Barrett Esophagus and Prostate Cancer.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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