Thermo Fisher Scientific BTLA Monoclonal Antibody (OTI9A10), TrueMAB
BTLA 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot과 유세포분석에 적합합니다. 동결건조 형태로 제공되며, PBS 버퍼에 8% 트레할로오스를 포함합니다. 연구용으로만 사용 가능하며, 세포 면역 반응 조절 연구에 활용됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9A10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 31–157 + Mouse Fc of human BTLA produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
BTLA (B and T-lymphocyte attenuator) is a co-inhibitory receptor belonging to the CD28 superfamily. It functions as a lymphocyte inhibitory receptor, modulating immune responses by inhibiting lymphocyte activation.
BTLA is constitutively expressed on most CD4⁺ and CD8⁺ T cells, with expression decreasing upon T cell activation. It remains expressed on Th1 cells but not on Th2 cells.
BTLA interacts with the TNF receptor superfamily member HVEM (herpesvirus entry mediator), forming an important pathway for regulating lymphocyte activation and homeostasis during immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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