Thermo Fisher Scientific PSEN2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1 µg/mL

-

Product Specifications

Host/Isotype

Chicken / IgY

Class

Polyclonal

Type

Antibody

Immunogen

Mixture of synthetic peptides corresponding to residues Y(319) D P E N E E D S Y D S(330) and G(349) E E L E E E E E R G V(360) of human PS2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PSEN2,uniProtId:P49810-1,ncbiNodeId:9606,antigenRange:319-330|349-360,antigenLength:448,antigenImageFileName:PA1-1753_PSEN2_P49810-1_Chicken.svg,antigenImageFileNamePDP:PA1-1753_PSEN2_P49810-1_Chicken_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2284396

Product Specific Information

PA1-1753 detects presenilin 2 protein (PS2) from human, rat and mouse samples.

PA1-1753 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~66 kDa protein representing PS2

The PA1-1753 immunogen is a mixture of synthetic peptides corresponding to residues Y(319) D P E N E E D S Y D S(330) and G(349) E E L E E E E E R G V(360) of human PS2.

Target Information

Alzheimer`s disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.