Thermo Fisher Scientific Presenilin 1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-2 µg/mL

-

Product Specifications

Host/Isotype

Chicken / IgY

Class

Polyclonal

Type

Antibody

Immunogen

Mixture of synthetic peptides corresponding to residues K(311) N S K Y N A E S T E R(322) and E(342) A Q R D S H L G P H R(353) of human PS1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Presenilin 1,uniProtId:P49768-1,ncbiNodeId:9606,antigenRange:312-322,antigenLength:467,antigenImageFileName:PA1-1752_Presenilin_1_P49768-1_Chicken.svg,antigenImageFileNamePDP:PA1-1752_Presenilin_1_P49768-1_Chicken_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2170599

Product Specific Information

PA1-1752 detects presenilin 1 protein (PS1) from human, rat and mouse samples.

PA1-1752 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~66 kDa protein representing PS1.

The PA1-1752 immunogen is a synthetic peptides corresponding to residues K(311) N S K Y N A E S T E R(322) and E(342) A Q R D S H L G P H R(353) of human PS1.

Target Information

Presenilin1 was initially identified a marker of susceptibility to early-onset Alzheimers disease. In addition to PEN2, nicastrin and APH-1, Presenilin1 forms the -gamma-secretase protein complex, a membrane-bound aspartyl protease that can cleave certain proteins at peptide bonds buried within the hydrophobic environment of the lipid bilayer. This cleavage is responsible for a key step in signaling from several cell-surface receptors and is thought to be required for the generation of the neurotoxic amyloid peptides that are central to the pathogenesis of Alzheimers disease. Like the tumor necrosis factor-alpha-converting enzyme (TACE) and the beta-site cleavage enzyme (BACE) protease families, -gamma-secretase will cleave the amyloid precursor protein (APP), but within the intramembrane region of APP, resulting in either the non-toxic p3 (from the alpha and -gamma cleavage site) or the toxic Abeta amyloid peptide (from the beta and -gamma cleavage site). It is thought that accumulation of the Abeta peptide is the precursor to Alzheimer`s disease. Multiple isoforms of presenilin1 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.