Thermo Fisher Scientific TAK1 Polyclonal Antibody
TAK1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot에 최적화되어 있으며, 여러 종(Bovine, Human, Mouse 등)에 반응합니다. 고순도 항원 친화 크로마토그래피로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- PA517507
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific TAK1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Bovine, Human, Mouse, Non-human primate, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues near the carboxy-terminus of human TAK1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 29 µg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979591 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
TAK1 (also known as MAP3K7) is a serine/threonine kinase involved in multiple signaling pathways. Initially identified as a TGF-β–activated kinase, TAK1 interacts with TGF-β receptor and TRAF6 to modulate activation of JNK and p38. It also participates in Wnt, BMP, and activin signaling, and responds to thyroid hormone, osmotic stress, endothelin, and ephrine.
Through activation of von Hippel-Lindau tumor suppressor expression, TAK1 represses PDGF-B, integrin β1, and integrin β5, promoting wound healing. TAK1 plays an essential role in IKK activation in pathways including IL-1, IL-6, IL-18, TNF, CD40, TLR, and RIG-I. Activation of the TAK1-IKK pathway requires TAB2/3 and ubiquitination, leading to TAK1 autophosphorylation and subsequent phosphorylation of IKK-β. TAK1 also represses human telomerase reverse transcriptase, suggesting a role in regulating cell lifespan.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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