Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI2D11), TrueMAB
Beta-catenin 단백질을 표적하는 Mouse monoclonal antibody로, Western blot에 최적화됨. Human 및 Dog 반응성. Lyophilized 형태로 제공되며, PBS buffer와 trehalose 함유. 세포 부착 및 신호전달 연구에 적합.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2D11 |
| Immunogen | Human recombinant protein fragment (aa 531–781 of human beta-catenin, produced in E. coli) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and signaling. It interacts with E-cadherin and alpha-catenin to anchor the adhesion complex to the actin cytoskeleton. Beta-catenin also associates with cytoskeletal and signaling complexes, influencing morphogenesis and cell proliferation through Lef/Tcf transcription factors.
Pathological roles have been identified in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other solid tumors (breast, colon, liver, lung, gastric, prostate, skin).
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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