Thermo Fisher Scientific CIDEA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• In Western blot applications, this antibody detects a band at approximately 23 kDa.
• Suggested positive control: human brain tissue lysate.
• PA5-19907 can be used with blocking peptide PEP-0033.

Target Information

This gene encodes the homolog of the mouse protein CIDEA that has been shown to activate apoptosis. This activation of apoptosis is inhibited by the DNA fragmentation factor DFF45 but not by caspase inhibitors.
Mice lacking functional CIDEA exhibit:

• Higher metabolic rates
• Increased lipolysis in brown adipose tissue
• Elevated core body temperatures under cold exposure
• Resistance to diet-induced obesity and diabetes

These findings suggest that CIDEA plays a role in thermogenesis and lipolysis. Alternatively spliced transcripts have been identified.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.