Thermo Fisher Scientific CamK4 Polyclonal Antibody
Rabbit 유래의 CaMKIV 폴리클로날 항체로, Western blot 및 Immunoprecipitation에 적합. 인간 CaMKIV의 350–400번 잔기 영역을 면역원으로 사용. 1 mg/mL 농도의 액상 형태로 제공되며 4°C 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution / Amount |
|---|---|
| Western Blot (WB) | 1:5,000–1:15,000 |
| Immunoprecipitation (IP) | 3–5 µg/mg lysate |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residues 350 and 400 of human Calcium/Calmodulin-dependent Protein Kinase IV |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells. The nuclear localization of this protein is consistent with its role in mediating calcium-dependent gene expression. CaMKIV is particularly abundant in testis, T-cells, and neurons but is also found in other tissues to varying degrees.
In neurons, CaMKIV plays an important role in synaptic plasticity via its gene regulatory effects. In T-cells, this protein contributes to calcium signaling, affecting transcription regulatory proteins such as NFAT. CaMKIV is encoded, along with calspermin, by the CaMKIV gene. In testes, CaMKIV is expressed in germ cells and associated with chromatin, suggesting a potential role in chromatin remodeling during nuclear condensation in spermatids.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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