Thermo Fisher Scientific TL1A Chimeric Recombinant Rabbit Monoclonal Antibody (TAN2-2)
TL1A 특이적 키메릭 재조합 토끼 단클론 항체로 다양한 면역분석(ICC/IF, Flow, Functional, Inhibition)에 사용 가능. HEK293 발현 시스템 기반, Protein A 정제, 1 mg/mL 농도. TL1A 관련 세포 신호 및 염증 연구에 적합.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Functional Assay (Functional)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | TAN2-2 |
| Immunogen | This antibody was raised by immunising rats with a soluble recombinant TL1A (T77-L252):Fc protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074592 |
Product Specific Information
This antibody is specific for TL1A, a member of the TNF ligand family. TL1A is expressed by endothelial cells, tissue macrophages, monocyte-derived dendritic cells, plasma cells, and lamina propria-derived lymphocytes. Among peripheral blood cells, TL1A is predominantly expressed by CD4+CCR9+ lymphocytes. Its expression is induced by TNF alpha, IL-1 alpha, and IFN gamma.
Target Information
The protein encoded by this gene is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is abundantly expressed in endothelial cells but not in B or T cells. Expression is inducible by TNF and IL-1 alpha. This cytokine binds to receptors TNFRSF25 and TNFRSF21/DR6, activates NF-kappaB and MAP kinases, and can induce apoptosis in endothelial cells. It may also function as an angiogenesis inhibitor. An additional isoform from an alternatively spliced transcript variant has been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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