Thermo Fisher Scientific TL1A Chimeric Recombinant Rat Monoclonal Antibody (TAN2-2)
TL1A 단백질을 표적으로 하는 Thermo Fisher Scientific의 TL1A Chimeric Recombinant Rat Monoclonal Antibody (TAN2-2). 다양한 면역학적 분석(ICC/IF, Flow Cytometry 등)에 사용 가능하며, 높은 특이성과 재현성을 제공. Protein A로 정제된 액상 형태로 제공.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Functional Assay (Functional)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rat / IgG2a, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | TAN2-2 |
| Immunogen | This antibody was raised by immunising rats with a soluble recombinant TL1A (T77-L252):Fc protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_3074593 |
Product Specific Information
This antibody is specific for TL1A, a member of the TNF ligand family. TL1A is expressed by endothelial cells, tissue macrophages, monocyte-derived dendritic cells, plasma cells, and lamina propria-derived lymphocytes. Among peripheral blood cells, TL1A is predominantly expressed by CD4+CCR9+ lymphocytes. Its expression is induced by TNF alpha, IL-1 alpha, and IFN gamma.
Target Information
The protein encoded by this gene is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. It is abundantly expressed in endothelial cells but not in B or T cells. Expression is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It activates NF-kappaB and MAP kinases and acts as an autocrine factor to induce apoptosis in endothelial cells. It also inhibits endothelial cell proliferation, functioning as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but its sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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