Thermo Fisher Scientific CD137 Chimeric Recombinant Rabbit Monoclonal Antibody (LOB12.3)
마우스 CD137(4-1BB)에 특이적으로 결합하는 재조합 토끼 단클론 항체입니다. ICC/IF, Flow Cytometry, ELISA, T-Cell Activation에 사용 가능합니다. Protein A로 정제된 액상 형태로 제공되며, 단기 4°C, 장기 -20°C 보관을 권장합니다.
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Applications 및 Tested Dilution
| Application | Tested Dilution | 참고 문헌 |
|---|---|---|
| Immunocytochemistry (ICC/IF) | 10 µg/mL | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
| ELISA | 0.0169 ng/mL | - |
| T-Cell Activation (TCA) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | LOB12.3 |
| Immunogen | This antibody was generated by immunizing rats with recombinant CD137-Fc fusion protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074590 |
Product Specific Information
Specificity: This antibody binds to mouse 4-1BB (CD137).
Target Information
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling supports the survival and clonal expansion of activated and memory T cells while suppressing myelopoiesis and dendritic cell development. Triggering of CD137 induces cytokine release that regulates peripheral monocyte survival. Soluble forms of CD137 may act as a negative control mechanism for certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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