Thermo Fisher Scientific JNK1 Monoclonal Antibody (M267)
JNK1 단백질을 검출하는 Thermo Fisher Scientific의 Mouse Monoclonal Antibody (Clone M267). Western Blot, IHC(F), ICC/IF에 적합하며 Human, Mouse, Rat 시료 반응. 고순도 Protein A 정제, PBS/BSA/glycerol buffer 구성으로 안정적 보관 가능.
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Thermo Fisher Scientific JNK1 Monoclonal Antibody (M267)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M267 |
| Immunogen | Clone M267 was generated from a recombinant protein corresponding to amino acid residues in the C-terminal region of human JNK1. This sequence has high homology to rat and mouse JNK1, and has homology to similar regions in JNK2 and JNK3. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~0.25 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1 mg/mL BSA, 50% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2942651 |
Product Specific Information
This antibody detects a 46 kDa* protein corresponding to the apparent molecular mass of JNK1 on SDS-PAGE immunoblots of human A431 and HeLa, as well as rat PC12 cells.
Target Information
MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing, with the predominant forms being JNK1 and JNK2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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