Thermo Fisher Scientific TPT1 Polyclonal Antibody
Rabbit polyclonal antibody targeting human TPT1 (aa 70-120). Validated for WB, IHC(P), and ICC/IF. High purity (>95%) and unconjugated form. Suitable for research use in studies of calcium-binding proteins and neurodegenerative disorders.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 70–120 of Human TPT1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718952 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is greater than 95% (by SDS-PAGE).
Target Information
TPT1 (translationally controlled tumor protein 1) is a 23 kDa member of the TCTP family of calcium-binding proteins. It is localized in the cytoplasm and widely expressed. TPT1 functions as a transcriptional activator, calcium transporter, histamine inducer, and antiapoptotic caspase 3 inhibitor. It acts as a cytokine-like molecule that induces the release of histamine, IL-4, and IL-13 from basophils, as well as IL-8 secretion and calcium response in eosinophils. TPT1 plays a pivotal role in allergic diseases and is implicated in neurodegenerative disorders such as Alzheimer’s disease and Down syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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