Thermo Fisher Scientific TSLP Receptor Monoclonal Antibody (eBio1A6 (1A6)), APC, eBioscience
인간 TSLP 수용체를 인식하는 eBio1A6 단클론 항체로, APC 형광 표지되어 유세포 분석에 최적화됨. IL-7Rα와 복합체를 형성하여 TSLP 결합에 관여하며, 면역세포 활성 및 Th2 관련 케모카인 발현 연구에 활용 가능. 연구용 전용 제품.
- 카탈로그번호
- 17-5499-4x (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TSLP Receptor Monoclonal Antibody (eBio1A6 (1A6)), APC, eBioscience
Thermo Fisher Scientific TSLP Receptor Monoclonal Antibody (eBio1A6 (1A6)), APC, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.06 µg)/test
Publications: View 2 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG2a, lambda |
| Recommended Isotype Control | Mouse IgG2a kappa Isotype Control (eBM2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio1A6 (1A6) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2573215 |
Additional Formats:
- Unconjugated
- PE
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 780
- Request custom conjugation
Product Specific Information
The eBio1A6 monoclonal antibody reacts with human thymic stromal-derived lymphopoietin receptor (TSLPR).
TSLPR is an approximately 50 kDa protein similar to the common gamma-chain and forms a high-affinity receptor complex with IL-7R alpha (CD127) to bind TSLP.
Human TSLPR is expressed by monocytes and CD11c+ dendritic cells. TSLP binding induces Th2 cell-attracting chemokines CCL17 and CCL22 expression.
Activation of dendritic cells through TSLPR increases secretion of IL-4, IL-5, and IL-13, which regulate CD4+ T cell homeostasis.
In mice, deficiency of TSLPR alone has no effect on lymphocyte numbers, while double deficiency of TSLPR and gamma-chain reduces lymphocytes compared to gamma-chain deficiency alone.
The eBio1A6 monoclonal antibody can cross-block binding of another anti-human TSLPR antibody, 1D8.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and validated using TSLPR-transfected cells
Recommended usage: 5 µL (0.06 µg) per test (100 µL final volume, 10^5–10^8 cells/test)
Excitation: 633–647 nm
Emission: 660 nm
Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Thymic stromal lymphopoietin (TSLP) drives dendritic cell maturation and activation.
It plays roles in:
- Regulatory T cell selection
- Peripheral CD4+ T cell homeostasis
- Induction of CD4+ T cell-mediated allergic responses
TSLP supports growth and differentiation of B cell progenitors to IgM-positive stages.
TSLP receptor (TSLP-R) binds TSLP with low affinity; co-expression with IL-7Rα forms a high-affinity, functional heteromeric complex.
This receptor complex requires STAT5 for signal transduction and is inhibited by SOCS-1.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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