Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (SPM514)
인간 p53 종양 억제 단백질을 인식하는 단클론 항체로, Western blot 및 IHC(PFA 고정)에 적합. 고순도 Protein A/G 정제, 200 µg/mL 농도, PBS 기반 저장액. 세포 스트레스 반응 및 암 연구용으로 최적화된 연구용 시약.
- 카탈로그번호
- 7157-MSM9X-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (SPM514)
Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (SPM514)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.25–0.5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM514 |
| Immunogen | Recombinant human full-length TP53 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. p53 up-regulates stress response genes such as p21waf1, leading to G1 or G2/M arrest.
Structurally, p53 includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerisation domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is crucial for activation and stabilization, while Ser392 phosphorylation is associated with tumor formation. p53 is expressed at low levels in normal cells but highly expressed in transformed cell lines, contributing to malignancy. Mutations in the TP53 gene are common in human cancers and lead to loss of tumor suppressor activity. Germline TP53 mutations are linked to cancer-prone syndromes such as Li-Fraumeni syndrome.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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