Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (TP53/1739)
인간 p53 종양 억제 단백질을 인식하는 단일클론 항체로, Western blot 및 면역조직화학 등 다양한 응용에 적합. 고순도 Protein A/G 정제, PBS 버퍼에 안정화되어 있으며 비결합형 액상 형태로 제공. 세포 스트레스 반응 및 암 연구에 유용.
- 카탈로그번호
- 7157-MSM9-Px (2개 옵션)
- 판매단위
- pk
카탈로그
2개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (TP53/1739)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 0.25–0.5 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | TP53/1739 |
| Immunogen | Recombinant full-length human TP53 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or pyrimidine nucleotide starvation. Upon stress, p53 activates transcription of genes such as p21waf1, leading to G1 or G2/M arrest.
Structurally, p53 includes:
- N-terminal transactivation domain
- Central DNA-binding domain
- Oligomerization domain
- C-terminal regulatory domain
Phosphorylation at Ser15 is critical for activation and stabilization. p53 blocks proliferation of damaged cells and acts as an anticancer agent. Phosphorylation at Ser392 is associated with tumor formation. It is also linked to aging, oxidative stress, and impaired learning due to reduced LTP.
Normal cells express p53 at low levels, while transformed cell lines show high expression, contributing to malignancy. Mutant p53 loses DNA binding and tumor suppressor activity. TP53 gene alterations occur in somatic mutations in cancers and germline mutations in Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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