Thermo Fisher Scientific MMP15 Polyclonal Antibody
MMP15 단백질을 인식하는 Rabbit Polyclonal 항체로, Human 및 Mouse 시료에 반응합니다. Western blot, IHC, Flow cytometry 등 다양한 응용에 사용 가능하며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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- PA513184
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- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 165–194 amino acids from the N-terminal region of human MMP15 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation, Size-exclusion, Dialysis |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2297836 |
Target Information
Matrix metalloproteinases (MMPs) are a group of enzymes involved in extracellular matrix degradation. Of the sixteen known members, ten exist in soluble form, whereas membrane-type MMPs (MT-MMPs) are integral membrane proteins. MT1-MMP (MMP14), MT2-MMP (MMP15), and MT3-MMP (MMP16) contain a C-terminal transmembrane domain anchoring them to the cell surface and possess an 8-amino acid insert in their catalytic domain.
MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B into their active forms. MT2-MMP plays a minor role in activating pro-MMP-2 in breast carcinomas, and coexpression of MT1-MMP and MT2-MMP in advanced breast carcinoma stages suggests possible involvement of MT2-MMP in metastasis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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