Thermo Fisher Scientific RAB7B Monoclonal Antibody (1C3)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

1C3

Immunogen

RAB7B (NP_796377, 100 a.a. approximately 199 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:RAB7B,uniProtId:Q96AH8-1,ncbiNodeId:9606,antigenRange:100-199,antigenLength:199,antigenImageFileName:H00338382-M02A_RAB7B_Q96AH8-1_House_mouse.svg,antigenImageFileNamePDP:H00338382-M02A_RAB7B_Q96AH8-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage buffer

ascites

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: DIWRGDVLAK IVPMEQSYPM VLLGNKIDLA DRKVPQEVAQ GWCREKDIPY FEVSAKNDIN VVQAFEMLAS RALSRYQSIL ENHLTESIKL SPDQSRSRCC

Target Information

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.