Thermo Fisher Scientific RAB43 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1–5 µg/mL

Product Specifications

Product Specific Information

Protein sequence:

MAGPGPGPGD PDEQYDFLFK LVLVGDASVG KTCVVQRFKT GAFSERQGST IGVDFTMKTL EIQGKRVKLQ IWDTAGQERF RTITQSYYRS ANGAILAYDI TKRSSFLSVP HWIEDVRKYA GSNIVQLLIG NKSDLSELRE VSLAEAQSLA EHYDILCAIE TSAKDSSNVE EAFLRVATEL IMRHGGPLFS EKSPDHIQLN SKDIGEGWGC GC

Target Information

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that recruits downstream effectors responsible for vesicle formation, movement, tethering, and fusion.

RAB43 has low intrinsic GTPase activity that is activated by USP6NL. It is involved in retrograde transport from the endocytic pathway to the Golgi apparatus and in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. RAB43 is required for the structural integrity of the Golgi complex and plays a role in the maturation of phagosomes that engulf pathogens such as S. aureus and M. tuberculosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.