Thermo Fisher Scientific RAB43 Monoclonal Antibody (4C11)
RAB43 단백질을 인식하는 Mouse IgG2a 단클론 항체로 Western blot 및 ELISA에 적합. 인간 반응성, 액상 형태, PBS buffer에 보존제 없이 제공. 세포 내 막 수송 및 골지체 기능 연구에 활용 가능.
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- H00339122-M09
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4C11 |
| Immunogen | RAB43 (NP_940892, 113–210 a.a) partial recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
IEDVRKYAGS NIVQLLIGNK SDLSELREVS LAEAQSLAEH YDILCAIETS AKDSSNVEEA FLRVATELIM RHGGPLFSEK SPDHIQLNSK DIGEGWGC
Target Information
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that recruits to membranes different sets of downstream effectors responsible for vesicle formation, movement, tethering, and fusion.
The low intrinsic GTPase activity of RAB43 is activated by USP6NL. It is involved in retrograde transport from the endocytic pathway to the Golgi apparatus and in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. RAB43 is required for the structural integrity of the Golgi complex and plays a role in the maturation of phagosomes that engulf pathogens such as S. aureus and M. tuberculosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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