Thermo Fisher Scientific RAB43 Monoclonal Antibody (4C11)

Applications

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
IEDVRKYAGS NIVQLLIGNK SDLSELREVS LAEAQSLAEH YDILCAIETS AKDSSNVEEA FLRVATELIM RHGGPLFSEK SPDHIQLNSK DIGEGWGC

Target Information

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that recruits to membranes different sets of downstream effectors responsible for vesicle formation, movement, tethering, and fusion.
The low intrinsic GTPase activity of RAB43 is activated by USP6NL. It is involved in retrograde transport from the endocytic pathway to the Golgi apparatus and in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. RAB43 is required for the structural integrity of the Golgi complex and plays a role in the maturation of phagosomes that engulf pathogens such as S. aureus and M. tuberculosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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