Thermo Fisher Scientific Phospho-PKC beta (Thr641) Polyclonal Antibody
PKC beta 단백질의 Thr641 인산화 부위를 인식하는 Rabbit Polyclonal Antibody로 Western blot, IHC, ICC/IF에 적합. Human, Mouse, Rat 반응성. 고순도 Affinity chromatography 정제, 1 mg/mL 농도, 연구용으로 사용.
- 카탈로그번호
- PA537692
- 판매단위
- pk
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Thermo Fisher Scientific Phospho-PKC beta (Thr641) Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:100–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide sequence around phosphorylation site of threonine 641 (E-L-T(p)-P-T) derived from Human PKC-beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2554300 |
Product Specific Information
- Suggested positive control for Western blot: JK cells
- Suggested positive control for IHC: Human lung carcinoma
- Suggested positive control for ICC/IF: MCF-7 cells
Target Information
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases activated by calcium and diacylglycerol. PKC family members phosphorylate diverse protein targets and participate in various cellular signaling pathways. They act as receptors for phorbol esters, known tumor promoters. Each PKC isoform has a distinct expression profile and cellular role, including B cell activation, apoptosis induction, endothelial proliferation, and intestinal sugar absorption. In mice, this kinase may regulate neuronal functions and stress-related behaviors. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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