Thermo Fisher Scientific CD16 Monoclonal Antibody (MEM-154), PE

Applications and Tested Dilution

• Flow Cytometry (Flow): 20 µL per 100 µL whole blood or 10⁶ cells
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Product Specifications

Additional Formats Available

• Unconjugated
• Biotin
• FITC
• Custom conjugation available upon request

Product Specific Information

This antibody reacts with CD16⁺ granulocytes and can be used for mapping CD16-158V/F polymorphism on NK cells, as it requires the presence of V at amino acid 158.

Target Information

CD16 encodes a receptor that recognizes the Fc portion of immunoglobulin G and is involved in immune complex clearance, cellular mediated cytotoxicity, and viral infection enhancement.
The gene FCGR3A shares high similarity with FCGR3B, both located on chromosome 1.

• FCGR3A: expressed on NK cells (transmembrane anchored)
• FCGR3B: expressed on polymorphonuclear neutrophils (PI-linked)

Mutations in FCGR3A are associated with:

• Immunodeficiency 20
• Susceptibility to recurrent viral infections
• Systemic lupus erythematosus
• Alloimmune neonatal neutropenia

Alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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