Thermo Fisher Scientific ARID1A Polyclonal Antibody
ARID1A 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ELISA에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 액상 제품으로, 1 mg/mL 농도. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1.0–2.0 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 5 µg/mL |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | 18 amino acid peptide near the amino terminus of human ARID1A (within amino acids 580–630 of ARID1A) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C (short term); -20°C for long term, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718715 |
Target Information
The ARID1A gene encodes a member of the SWI/SNF family with helicase and ATPase activities, involved in chromatin remodeling and transcription regulation. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, essential for transcriptional activation of genes typically repressed by chromatin. It includes:
- A DNA-binding domain recognizing AT-rich sequences at the beta-globin locus
- A C-terminal domain that stimulates glucocorticoid receptor-dependent transcriptional activation
This protein confers specificity to the SNF/SWI complex and may recruit it to target genes via protein-DNA or protein-protein interactions. Two transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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