
Thermo Fisher Scientific ITGB1BP1 Monoclonal Antibody (OTI4E1), TrueMAB
Thermo Fisher Scientific의 ITGB1BP1 단클론 항체(OTI4E1)는 인간 시료에 반응하며 Western blot에 최적화되어 있습니다. 완전 길이 인간 재조합 단백질로부터 제작되었으며, 동결건조 형태로 제공됩니다. 세포 부착 및 이동 관련 연구에 적합합니다.
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Applications
- Western Blot (WB): 1:2,000 dilution tested
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E1 |
| Immunogen | Full length human recombinant protein of human ITGB1BP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
ITGB1BP1 is a key regulator of integrin-mediated cell-matrix interaction signaling. It binds to the ITGB1 cytoplasmic tail, preventing activation of integrin α5β1 by talin or FERMT1.
It plays important roles in:
- Cell proliferation, differentiation, spreading, adhesion, and migration
- Bone development and angiogenesis
- Regulation of β1 integrin-containing focal adhesion dynamics
- Modulation of Rho GTPase activity (CDC42, RAC1)
- ROCK1 translocation and myoblast migration
- Bone mineralization and fibronectin fibrillogenesis
- Negative regulation of angiogenesis via Notch signaling and AKT/ERK phosphorylation balance
- Promotion of MYC promoter transcriptional activity
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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