Thermo Fisher Scientific Patched1 Monoclonal Antibody (OTI5G9), TrueMAB
Human PTCH1 단백질(aa 770-1027)에 특이적인 Mouse monoclonal antibody입니다. Western blot에 최적화되어 있으며, Lyophilized 형태로 제공됩니다. PBS buffer(8% trehalose)로 안정화되어 있으며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5G9 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 770–1027 of human PTCH1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, it is recommended to perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
The PTCH1 gene encodes a member of the patched gene family. The encoded protein is a receptor for sonic hedgehog, desert hedgehog, and indian hedgehog proteins—key molecules involved in embryonic development and tumorigenesis.
PTCH1 functions as a tumor suppressor, and mutations are associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinoma of the bladder, and holoprosencephaly.
Multiple transcript variants and isoforms are known, though some remain incompletely characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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