Thermo Fisher Scientific C9orf72 Polyclonal Antibody
Human C9orf72 단백질을 인식하는 닭 유래 IgY 폴리클로날 항체. IHC, Flow Cytometry, ELISA 등 다양한 응용 가능. 고순도 액상 형태로 제공되며 장기 보관 시 -20°C에서 안정적. 신경퇴행성 질환 연구용으로 적합.
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Thermo Fisher Scientific C9orf72 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (IHC) | 1:200 |
| Flow Cytometry (Flow) | 1:20 |
| ELISA | 1:10,000–1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Chicken / IgY |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to C-terminal portion of human C9orf72 (aa 425–481) conjugated to Keyhole Limpet Hemocyanin (KLH) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.03 mg/mL |
| Purification | Selective precipitation |
| Storage Buffer | PBS, pH 7 |
| Contains | 0.01% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Store vial at -20°C prior to opening.
- Aliquot contents and freeze at -20°C or below for extended storage.
- Avoid cycles of freezing and thawing.
- Centrifuge product if not completely clear after standing at room temperature.
- Stable for several weeks at 4°C as undiluted liquid.
- Dilute only prior to immediate use.
This affinity-purified antibody is directed against human C9orf72. The IgY fraction was purified from monospecific chicken egg yolks via selective precipitation and salt fractionation, followed by extensive dialysis.
BLAST analysis indicates cross-reactivity with mouse and rat based on 100% homology with the immunizing sequence.
Target Information
C9orf72 may play roles in endosomal trafficking and autophagy. It interacts with HNRNPA1, HNRNPA2B1, UBQLN2, and small Rab GTPases. Localization includes nucleus, cytoplasm, endosome, lysosome, and autophagosome.
Mutations in C9orf72 are associated with frontotemporal dementia and amyotrophic lateral sclerosis (ALS).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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