Thermo Fisher Scientific SNAIL Monoclonal Antibody (F.31.8)
SNAIL 단백질을 인식하는 Rabbit Monoclonal Antibody로, Western blot, ICC/IF, IP 등에 사용 가능. 인간 및 설치류 등 다양한 종에 반응하며, EMT 연구 및 암 침윤 관련 연구에 적합. 고순도 Affinity chromatography 정제, 안정적 액상 형태로 제공.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 8 publications |
| Immunocytochemistry (ICC/IF) | 1:250 | View 2 publications |
| Immunoprecipitation (IP) | 1:50 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F.31.8 |
| Immunogen | Recombinant human Snail protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 110 µg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 100 µg/mL BSA, 50% glycerol |
| Contains | <0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_10981481 |
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
Zinc finger protein SNAI1 (SNAIL) is a zinc finger transcriptional repressor that downregulates ectodermal gene expression within the mesoderm and functions in mesoderm and neural crest formation. SNAI1 is an important factor in tumor invasion, associated with E-cadherin down-regulation and induction of epithelial-mesenchymal transition (EMT). In human breast cancer, SNAI1 and/or SNAI2 (Slug) expression correlates with E-cadherin repression, metastasis, recurrence, and poor prognosis. Snail 1 protein in stroma may serve as a putative prognostic marker for colon tumors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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